The Role of Rora (Rar-Related Orphan Receptor Alpha) Receptors, One of The Candidate Genes Identified for Sheep Reproductive Traits, In Sheep Reproduction

RORA (RAR-Related Orphan Receptor Alpha) regulates estrogen synthesis by transcribing steroid related genes. Litter size is an important reproductive trait associated with synthesis. Therefore, it critical to investigate the relationship between gene and sheep litter size. In this study, a 23 base pair nucleotide sequence mutation in called effect of on productivity offspring were investigated. bp was found intron 1 35 female Bafra ewes. Ten ml milk collected from each samples. The DD genotype significantly higher than ID II second born (p> 0.05). combined genotypes average showed that ewes homozygous (DD) had larger lambs heterozygous (ID) genotype. Multiple pregnancy rates first litters stillbirth rate To summarize, study provided theoretical references for further research function breeding sheep. 23-bp indel variants can be used as molecular markers MAS (marker assisted selection) breeding.